Louisville, the only No. 1 seed still alive, defeated Duke 85-63 Sunday afternoon to complete the field for the NCAA Final Four next weekend.
The Cardinals ran Duke out of the game during the second half and used several three-pointers to run away with the victory in Indianapolis.
Joining the Cardinals in next Saturday's action in Atlanta will be Wichita State, Michigan and Syracuse.
Louisville will meet ninth-seeded Wichita State in one semifinal game while Michigan and Syracuse, both fourth seeds -- will meet in the other semifinal.
Syracuse defeated top-seeded Indiana on Saturday while Michigan ousted No. 3 Florida in Sunday's early game for the South Regional title.
Wichita State eliminated Ohio State 70-66 on Saturday to claim the West Regional crown in Los Angeles.
The winners will advance to the championship game on April 8.